AELAB LGJ-200F / LGJ-300F Silicon Oil Heating Freeze Dryer for Pilot-Scale Lyophilization

The AELAB LGJ-200F/300F silicon oil heating freeze dryer integrates a dual-color touch screen and PLC controller to ensure stable, reliable operation during lyophilization. The system supports 33 groups of freeze-drying programs, each containing up to 36 segments, enabling precise and repeatable control of temperature, vacuum, and drying curves.

Freeze-drying data can be exported via USB flash disk for GLP documentation. Designed for pilot-scale and small-scale production, the LGJ-200F/300F models use cascade refrigeration with two compressors to reach condenser temperatures below −75 °C. Samples can be frozen and dried directly on the shelves, supported by an air-cooling system for easy installation and operation.

⚙️ Design & Construction

The AELAB LGJ-200F/LGJ-300F freeze dryer features high-strength Stainless Steel plates, precision-machined shelves, and a chamber tested by helium mass spectrometry for leak integrity. Silicon-oil heating ensures accurate ±0.5 °C temperature control. The refrigeration system uses a Bitzer compressor with multiple oil-pressure and motor-protection functions. An HMI interface displays valve status, vacuum level, shelf temperature, and process progress, enabling safe, aseptic operation.

🔬 Working Principle / Testing Method

The freeze dryer operates by freezing samples on Stainless Steel shelves and applying controlled vacuum (<5 Pa) to induce sublimation. Cascade refrigeration maintains the condenser at <-75 °C, efficiently capturing water vapor (30 kg/24 h for LGJ-200F and 60 kg/24 h for LGJ-300F). Silicon oil circulates through the shelf system to stabilize thermal uniformity. Defrosting is performed by water soaking for rapid condenser recovery.

💡 Key Advantages

• Precise silicon-oil temperature regulation with ±0.5 °C control accuracy
• High condenser capacity enabling large-volume pilot-scale freeze-drying
• Cascade refrigeration provides reliable cooling performance below −75 °C
• USB data export supports GLP documentation and traceability
• HMI visual monitoring for shelves, valves, vacuum, and temperature
• Multiple interlock protections for compressors and refrigeration circuits
• Optional ozone disinfection enhances chamber asepsis

🔗 Connectivity & Integration

The AELAB LGJ-200F/LGJ-300F integrates PLC-based digital control with USB data export for batch records. The interface supports parameter setting, step skipping, and real-time monitoring. External connections support auxiliary refrigeration safety and compressor protection systems.

🧠 Model Insight

🧪 Testing Applications

This freeze dryer is suitable for laboratory and industrial lyophilization of pharmaceuticals, biological samples, vaccines, enzymes, plant extracts, food materials, and high-value temperature-sensitive products. It supports pilot manufacturing, formulation research, and small-scale production environments.

Compliance & Quality Assurance

The AELAB LGJ series is manufactured under CE and ISO-aligned quality protocols. Each unit undergoes helium leakage testing, compressor safety verification, and calibration traceability to ensure long-term stability in GLP-compliant laboratories.