This paper compares Gas Chromatography (GC) and High-Performance Liquid Chromatography (HPLC), highlighting their key differences, advantages, and limitations. GC uses gas as the mobile phase, suitable for volatile and thermally stable compounds, while HPLC employs liquid phases, ideal for non-volatile, polar, and large biomolecules. The paper also discusses detection principles, operational costs, and sample requirements. It provides insights into their industrial applications, emphasizing the selection criteria based on sample properties and analysis goals.
